Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Three-dimensional reconstruction of fracture callus morphogenesis Three-dimensional reconstruction of fracture callus morphogenesis |
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Document Language |
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English |
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Abstract |
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Rat and mouse femur and tibia fracture calluses were collected over various
time increments of healing. Serial sections were produced at spatial segments
across the fracture callus. Standard histological methods and in situ
hybridization to col1a1 and col2a1 mRNAs were used to define areas of
cartilage and bone formation as well as tissue areas undergoing remodeling.
Computer-assisted reconstructions of histological sections were used to
generate three-dimensional images of the spatial morphoge nesis of the fracture
calluses. Endochondral bone formation occurred in an asymmetrical manner in
both the femur and tibia, with cartilage tissues seen primarily proximal or
distal to the fractures in the respective calluses of these bones. Remodeling of
the calcified cartilage proceeded from the edges of the callus inward toward
the fracture producing an inner-supporting trabecular structure over which a
thin outer cortical shell forms. These data suggest that the specific
developmental mechanisms that control the asymmetrical pattern of
endochondral bone formation in fracture healing recapitulated the original
asymmetry of development of a given bone because femur and tibia grow
predominantly from their respective distal and proximal physis. These data
further show that remodeling of the calcified cartilage produces a trabecular
bone structure unique to fracture healing that provides the rapid regain in
weight-bearing capacity to the injured bone. |
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ISSN |
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0 |
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Journal Name |
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Journal of Histochemistry & Cytochemistry |
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Volume |
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54 |
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Issue Number |
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11 |
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Publishing Year |
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2006 AH
2006 AD |
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Article Type |
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Article |
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Added Date |
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Friday, January 4, 2008 |
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Researchers
| ياسر الخياري | Alkhiary, Yaser | Investigator | Doctorate | YALKHIARY@Kau.edu.sa |
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